Ở nồng độ 10 μg/ml thì cao phân đoạn ethylacetat được xem là ức chế SOD
mạnh nhất (58,91%), so với còn 5 mẫu cao còn lại nhưng tác dụng ức chế SOD
không tốt bằng tác dụng của quercetin (với tỷ lệ ức chế đạt 95,50%).
6 mẫu cao này tiếp tục được xác định IC50 với quercetin là chất đối chiếu thu
được kết quả như sau:
IC50: Cao ethanol = 12,33μg/ml; cao phân đoạn n- hexan = 94,03μg/ml; cao
phân đoạn dicloromethan = 25,26μg/ml; cao ethyl cacetat = 8,382/ml ; cao phân
đoạn n- butanol; Cao nước không tính do liều IC50 quá lớn. Kết quả cho thấy khả
năng dọn gốc tự do SOD của cao phân đoạn ethyl acetat là mạnh nhất
Từ hai thí nghiệm thử tác dụng dọn gốc tự do DPDH và SOD thấy được rằng
cao chiết muồng lùn có tác dụng chống oxy hóa và khả năng chống oxy hóa mạnh
nhất là ở cao phân đoạn ethyl acetat.
Các hợp chất phân lập được chưa được đánh giá tác dụng chống oxy hóa in
vitro tuy nhiên, tổng quan tài liệu cho kết quả, một số hợp chất trong số này thể
hiện tác dụng chống oxy hóa thông qua một số cơ chế khác nhau. Hợp chất TB6.4
(Liquiritigenin) có tác dụng chống oxy hóa in vitro thông qua khả năng ức chế
hình thành gốc tự do ABTS•+ [20]. Về cơ chế tác dụng, trong tế bào chất, protein
KEAP1 thường được liên kết với NRF2 để ổn định nó trong tế bào chất.
Liquiritigenin liên kết với KEAP1, khiến NRF2 giải phóng khỏi phức hợp protein
và chuyển vị trí vào nhân. Trong nhân, NRF2 liên kết với các yếu tố phản ứng
chống oxy hóa (AREs), bắt đầu phản ứng chống oxy hóa, do đó làm giảm sản xuất
các gốc oxy phản ứng quá mức ( ROS) nội bào và làm giảm độc tính tế bào do
quá trình oxy hóa gây ra [141]. Hợp chất TB3.10 thể hiện tác dụng chống oxy hóa
thông qua tác dụng khử tyrosinase [86], loại bỏ gốc tự do DPPH và superoxide,
ức chế xanthine oxidase, ức chế sản xuất MMP-1 [80]; điều chỉnh giảm sự biểu
hiện của gen tiền apoptotic Txnip và Ddit3 và ngoài ra còn điều chỉnh tăng biểu
hiện của các gen phản ứng chống oxy hóa Hmox1, Nqo1 và Sod1 [96]. Trong một
nghiên cứu của Suresh G và các cộng sự (2012), hợp chất TB12.10 ((-)- festidinol)
được phân lập trong cao chiết methanol của loài Dichrostachys cinerea đã được
đánh giá khả năng tách gốc tự do và ức chế sản phẩm glycation tiên tiến (AGE);
(-)- festidinol được tìm thấy là chất ức chế AGE tự nhiên mới [117].
Dựa trên cơ sở kết quả đánh giá tác dụng chống oxy hóa trên in vitro chúng
tôi tiếp tục tiến hành thử tác dụng dược lý trên động vật thực nghiệm và phân lập
chất hóa học.
153 trang |
Chia sẻ: Kim Linh 2 | Ngày: 09/11/2024 | Lượt xem: 50 | Lượt tải: 0
Bạn đang xem trước 20 trang tài liệu Luận án Nghiên cứu đặc điểm thực vật, thành phần hóa học và một số tác dụng sinh học của loài muồng lùn [Chamaecrista pumila (Lam.) K.Larsen], để xem tài liệu hoàn chỉnh bạn click vào nút DOWNLOAD ở trên
Natural Product Research, (3), pp. 1-10.
129
TÀI LIỆU THAM KHẢO
I. TÀI LIỆU TIẾNG VIỆT
1. Nguyễn Tiến Bân (2003), Danh lục các loài thực vật Việt Nam, tập 3, Nhà xuất
bản Nông nghiệp, Hà Nội.
2. Võ Văn Chi (2012), Từ điển cây thuốc Việt Nam, Tập 2, Nhà xuất bản Y học, Hà
Nội.
3. Nguyễn Văn Đàn and Nguyễn Viết Tựu (1985), Phương pháp nghiên cứu hóa học
cây thuốc, Nhà xuất bản Y học, Hà Nội.
4. Phạm Hoàng Hộ (1999), Cây cỏ Việt Nam, Vol. Tập 1-3, Nhà xuất bản trẻ, Tp Hồ
Chí Minh.
5. Trần Công Khánh và Nguyễn Thị Sinh (1997), Thực vật dược – Phân loại thực
vật, Trường Đại học Dược Hà Nội, Hà Nội.
6. Trần Văn Ơn (2003), Thực vật và nhận thức cây thuốc, Trường Đại học Dược Hà
Nội, Hà Nội.
7. Trần Văn Sung (2002), "Phổ cộng hưởng từ hạt nhân trong hóa hữu cơ", Nhà xuất
bản Đại học Quốc gia, Hà Nội.
8. Nguyễn Viết Thân (1998), Thực tập dược liệu – phần vi học, Trường Đại học Dược
Hà Nội, Hà Nội.
9. Nguyễn Viết Thân (2003), Kiểm nghiệm dược liệu bằng phương pháp hiển vi, Nhà
xuất bản Khoa học và Kỹ thuật, Hà Nội.
10. Viện Dược liệu (2006), Nghiên cứu thuốc từ thảo dược (Giáo trình sau đại học),
Nhà xuất bản Khoa học Kỹ thuật, Hà Nội.
II. TÀI LIỆU TIẾNG ANH
11. Beauchamp, C., Fridovich, Irwin (1971), "Superoxide dismutase: improved assays
and an assay applicable to acrylamide gels", Analytical biochemistry, 44(1), pp.
276-287.
12. Chen, Y.-C., Sugiyama, Y., Abe, N., et al. (2005), "DPPH radical-scavenging
compounds from dou-chi, a soybean fermented food", Bioscience, biotechnology,
and biochemistry, 69(5), pp. 999-1006.
13. Girish, C., Koner, BC,Jayanthi, S,Rao, KR, Rajesh, B,Pradhan, SC, (2009),
"Hepatoprotective activity of six polyherbal formulations in paracetamol induced
liver toxicity in mice", The Indian Journal Medical Research, pp. 569-578.
130
14. Saito, S., Okamoto, Y., and Kawabata, J. (2004), "Effects of alcoholic solvents on
antiradical abilities of protocatechuic acid and its alkyl esters", Bioscience,
biotechnology, and biochemistry, 68(6), pp. 1221-1227.
15. Stroev, E. and Makarova, V. (1989), "Determination of lipid peroxidation rate in
tissue homogenate laboratory", Laboratory manual in biochemistry, pp. 243-256.
16. Ahmad, S., Hassan, A., Abbasi, W.M., et al. (2018), "Phytochemistry and
pharmacological potential of Cassia absus - a review", Journal of Pharmacy and
Pharmacology, 70(1), pp. 27-41.
17. Ahmad, S., Hassan, A., Rehman, T., et al. (2019), "In vitro bioactivity of extracts
from seeds of Cassia absus L. growing in Pakistan", Journal of Herbal Medicine,
16, p. 100258.
18. Akah, P., Orisakwe, O., Gamaniel, K., et al. (1998), "Evaluation of Nigerian
traditional medicines: II. Effects of some Nigerian folk remedies on peptic ulcer",
Journal of ethnopharmacology, 62(2), pp. 123-127.
19. Ali, M.S., Jahangir, M., Hussan, S.S., et al. (2002), "Inhibition of alpha-
glucosidase by oleanolic acid and its synthetic derivatives", Phytochemistry, 60(3),
pp. 295-299.
20. Alrushaid, S., Davies, N.M., Martinez, S.E., et al. (2016), "Pharmacological
characterization of liquiritigenin, a chiral flavonoid in licorice", Research in
Pharmaceutical Sciences, 11(5), pp. 355-365.
21. Anu, S.J. and Rao, J.M. (2001), "Oxanthrone esters from the aerial parts of Cassia
kleinii", Phytochemistry, 57(4), pp. 583-585.
22. Ayo, R.G., Amupitan, J.O., Ndukwe, G.l., et al. (2009), "Some chemical
constituents of the leaves of Cassia nigricans Vahl", African Journal of Pure and
Applied Chemistry, 3(11), pp. 208-211.
23. Ayo, R.G., Amupitan, J.O., and Zhao, Y.M. (2007), "Cytotoxicity and
antimicrobial studies of 1, 6, 8-trihydroxy-3-methyl-anthraquinone (emodin)
isolated from the leaves of Cassia nigricans Vahl", African Journal of
Biotechnology, 6(11), pp. 1276-1279.
24. Aziz, N., Kim, M.Y., and Cho, J.Y. (2018), "Anti-inflammatory effects of luteolin:
A review of in vitro, in vivo, and in silico studies", Journal of Ethnopharmacology
225, pp. 342-358.
25. Babu, V., Gangadevi, T., and Appian, S. (2003), "Antidiabetic activity of ethanol
extract of Cassia kleinii leaf in streptozotocin induced diabetic rats and isolation
of an active fraction and toxicity evaluation of the extract", Journal of
Pharmacology, 35, pp. 290-296.
131
26. Baliyan, S., Mukherjee, R., Priyadarshini, A., et al. (2022), "Determination of
Antioxidants by DPPH Radical Scavenging Activity and Quantitative
Phytochemical Analysis of Ficus religiosa", Molecules, 27(4), p. 1326.
27. Barba, B., G. Díaz, J., and Herz, W. (1994), "Cassanes and anthraquinones from
Chamaecrista greggii", Phytochemistry, 37(3), pp. 837-845.
28. Batwal, R. and Argade, N. (2016), "Chemoenzymatic access to (+)-artabotriol and
its application in collective synthesis of (+)-grandiamide D, (–)-tulipalin B, (+)-
spirathundiol, and (+)-artabotriolcaffeate", Synthesis, 48(13), pp. A-G.
29. Belmain, S.R., Neal, G.E., Ray, D.E., et al. (2001), "Insecticidal and vertebrate
toxicity associated with ethnobotanicals used as post-harvest protectants in
Ghana", Food and Chemical Toxicology, 39(3), pp. 287-291.
30. Brown, J.E. and Rice-Evans, C.A. (1998), "Luteolin-rich artichoke extract protects
low density lipoprotein from oxidation in vitro", Free Radical Research, 29(3), pp.
247-255.
31. Bruschi, S.A. (205), "Methods and approaches to study metabolism and toxicity of
acetaminophen", Drug Metabolism and Transport, Springer, pp. 197-232.
32. Çalışkan, D., Koca, T., Doğuç, D.K., et al. (2016), "The protective effect of
pomegranate juice in paracetamol-induced acute hepatotoxicity in rats", Turkish
Pediatric Association, 51(2), pp. 72-78.
33. Chiou, Y.-S., Tsai, M.-L., Nagabhushanam, K., et al. (2011), "Pterostilbene is
more potent than resveratrol in preventing azoxymethane (AOM)-induced colon
tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated
antioxidant signaling pathway", Journal of Agricultural and Food Chemistry,
59(6), pp. 2725-2733.
34. Choi, R.J., Ngoc, T.M., Bae, K., et al. (2013), "Anti-inflammatory properties of
anthraquinones and their relationship with the regulation of P-glycoprotein
function and expression", European Journal of Pharmaceutical Sciences, 48(1),
pp. 272-281.
35. Choo, Q.-Y., Yeo, S.C.M., Ho, P.C., et al. (2014), "Pterostilbene surpassed
resveratrol for anti-inflammatory application: Potency consideration and
pharmacokinetics perspective", Journal of Functional Foods, 11, pp. 352-362.
36. Conti, M., Malandrino, S., and Magistretti, M.J. (1992), "Protective activity of
silipide on liver damage in rodents", Japanese Journal of Pharmacology, 60(4),
pp. 315-321.
37. Cooper, A.J. and Kristal, B.S. (1997), "Multiple roles of glutathione in the central
nervous system", Journal of Biological Chemistry, 378(8), pp. 793-802.
132
38. Daulat, S., K., S.S., S., S.M., et al. (2012), "Screening of some glycosidic
flavonoids and their antimicrobial activity of Cassia pumila Lamk", Asian Journal
of Research in Chemistry, 5(2), pp. 305-311.
39. Dave, H. and Ledwani, L. (2012), "A review on anthaquinones isolated from
Cassia species and their applications", Indian Journal of Natural Products and
Resources, 3, pp. 291-319.
40. David, J.P., Meira, M., David, J.M., et al. (2007), "Radical scavenging, antioxidant
and cytotoxic activity of Brazilian Caatinga plants", Fitoterapia, 78(3), pp. 215-
218.
41. Ding, Y., Liu, P., Chen, Z.L., et al. (2018), "Emodin attenuates lipopolysaccharide-
induced acute liver injury via inhibiting the TLR4 signaling pathway in vitro and
in vivo", Frontiers in Pharmacology, 9, p. 962.
42. Dirsch, V.M., Stuppner, H., and Vollmar, A.M. (1998), "The Griess assay: suitable
for a bio-guided fractionation of anti-inflammatory plant extracts?", Planta
Medica, 64(5), pp. 423-426.
43. Dongre, S. and Dhabe, A. (2020), "Morphological characters of genus
Chamaecrista Moench and its species from Maharashtra", BIOINFOLET, 16, pp.
44-47.
44. Ekwueme, F.N., Oje, O.A., Nwodo, O.F.C., et al. (2011), "Anti-inflammatory
capacity of the aqueous leaf extract of Senna mimosoides on inhibition of rat
oedema, platelet aggregatory activity and prostaglandin synthase activity ",
Journal of Medicinal Plants Research, 5(14), pp. 3028-3036.
45. El-Beshbishy, H.A., Mohamadin, A.M., and Abdel-Naim, A.B. (2009), "In vitro
evaluation of the antioxidant activities of grape seed (Vitis vinifera) extract,
blackseed (Nigella sativa) extract and curcumin", Journal of Taibah University
Medical Sciences, 4(1), pp. 23-35.
46. Georges, K., Jayaprakasam, B., Dalavoy, S.S., et al. (2008), "Pest-managing
activities of plant extracts and anthraquinones from Cassia nigricans from Burkina
Faso", Bioresource Technology, 99(6), pp. 2037-2045.
47. Gomes, P., Quirós-Guerrero, L., Muribeca, A., et al. (2021), "Constituents of
Chamaecrista diphylla (L.) Greene leaves with potent antioxidant capacity: A
feature-based molecular network dereplication approach", Pharmaceutics, 13(5),
p. 681.
48. Gonza´lez, A.G., Barrera, J.B., Davila, B.B., et al. (1992), "Anthraquinones from
Cassia greggii", Phytochemistry, 31(1), pp. 255-258.
49. Gupta, A. (2010), "Sub acute toxicity studies of paracetamol infusion in Albino
Wistar rat", International Journal of Pharmaceutical Sciences and Drug Research,
2(2), pp. 142-145.
133
50. Hamedi, A., Khoshnoud, M., Tanideh, N., et al. (2015), "Reproductive toxicity of
Cassia absus seeds in female rats: Possible progesteronic properties of chaksine
and β-sitosterol", Pharmaceutical Chemistry Journal, 49(4), pp. 268-274.
51. Herrero Uribe, L., Chaves Olarte, E., and Tamayo Castillo, G. (2004), "In vitro
antiviral activity of Chamaecrista nictitans (Fabaceae) against herpes simplex
virus: biological characterization of mechanisms of action", Revista de Biología
Tropical, 52(3), pp. 807-816.
52. Hong, E.H., Heo, E.Y., Song, J.H., et al. (2017), "Trans-scirpusin A showed
antitumor effects via autophagy activation and apoptosis induction of colorectal
cancer cells", Oncotarget, 8(25), pp. 41401-41411.
53. Hosamani, K.M. (1994), "A rich source of novel 9-ketooctadec-cis-15-enoic acid
from Cassia absus seed oil and its possible industrial utilization", Industrial &
Engineering Chemistry Research, 33(4), pp. 1058-1061.
54. Hou, Y., Li, N., Xie, G., et al. (2015), "Pterostilbene exerts anti-neuroinflammatory
effect on lipopolysaccharide-activated microglia via inhibition of MAPK
signalling pathways", Journal of Functional Foods, 19, pp. 676-687.
55. Hu, Q.F., Niu, D.Y., Zhou, B., et al. (2013), "Isoflavanones from the stem of
Cassia siamea and their anti-tobacco mosaic virus activities", Bulletin of the
Korean Chemical Society, 34(10), pp. 3013-3016.
56. Huang, Z., Sheng, Y., Chen, M., et al. (2018), "Liquiritigenin and liquiritin
alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system",
Toxicology and Applied Pharmacology, 355, pp. 18-27.
57. Hussain, H.S.N. and Deeni, Y.Y. (1991), "Plants in Kano ethnomedicine;
screening for antimicrobial activity and alkaloids", International Journal of
Pharmacognosy, 29(1), pp. 51-56.
58. Jaeschke, H., Williams, C.D., McGill, M.R., et al. (2013), "Models of drug-
induced liver injury for evaluation of phytotherapeutics and other natural
products", Food and Chemical Toxicology, 55, pp. 279-289.
59. Jeong, S.O., Son, Y., Lee, J.H., et al. (2015), "Resveratrol analog piceatannol
restores the palmitic acid-induced impairment of insulin signaling and production
of endothelial nitric oxide via activation of anti-inflammatory and antioxidative
heme oxygenase-1 in human endothelial cells", Molecular Medicine Reports,
12(1), pp. 937-944.
60. Jida, Z., Yingjie, H., Wen, Z., et al. (2009), "Chemical constituents of Cassia
mimosoides Linn", Journal of Tropical and Subtropical Botany, 17, pp. 80-82.
61. John, S., Kale, M., Rathore, N., et al. (2001), "Protective effect of vitamin E in
dimethoate and malathion induced oxidative stress in rat erythrocytes", Journal of
Nutritional Biochemistry, 12(9), pp. 500-504.
134
62. Kanbur, M., Eraslan, G., Beyaz, L., et al. (2009), "The effects of royal jelly on liver
damage induced by paracetamol in mice", Experimental and Toxicologic
Pathology, 61(2), pp. 123-132.
63. Khaled, S., Imed, S., Zouhir, A., et al. (2014), "Phylogenetic identification,
phytochemical analysis and antioxidant activity of Chamaecrista absus var. absus
seeds", Journal of Plant Biology Research, 3(1), pp. 1-11.
64. Kim, J.S., Kwon, C.S., and Son, K.H. (2000), "Inhibition of alpha-glucosidase and
amylase by luteolin, a flavonoid", Bioscience Biotechnology and Biochemistry,
64(11), pp. 2458-2461.
65. Kim, Y.W., Ki, S.H., Lee, J.R., et al. (2006), "Liquiritigenin, an aglycone of
liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by
acetaminophen with or without buthionine sulfoximine", Chemico-Biological
Interactions, 161(2), pp. 125-138.
66. Kim, Y.W., Zhao, R.J., Park, S.J., et al. (2008), "Anti-inflammatory effects of
liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS
and proinflammatory cytokines production", British Journal of Pharmacology,
154(1), pp. 165-173.
67. Kitanaka, S. and Takido, M. (1985), "Anthraquinoids from Cassia nomame",
Journal of Natural Products, 48(5), pp. 849-849.
68. Kobayashi, M., Mahmud, T., Yoshioka, N., et al. (2010), "Indonesian medicinal
plants. XVIII. Kompasinol A, a new stilbeno-phenylpropanoid from the bark of
Koompassia malaccensis (Fabaceae)", Chemical and Pharmaceutical Bulletin,
44(12), pp. 2249-2253.
69. Koh, P.H., Mokhtar, R.A., and Iqbal, M. (2012), "Antioxidant potential of
Cymbopogon citratus extract: alleviation of carbon tetrachloride-induced hepatic
oxidative stress and toxicity", Human and Experimental Toxicology, 31(1), pp. 81-
91.
70. Kong, G.H., Wu, Y.P., Li, Y.K., et al. (2018), "Three new chromone derivatives
from Cassia pumila and their anti-tobacco mosaic virus activity", Heterocycles,
96(12), pp. 2119-2125.
71. Kong, L.D., Zhang, Y., Pan, X., et al. (2000), "Inhibition of xanthine oxidase by
liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis",
Cellular and Molecular Life Sciences, 57(3), pp. 500-505.
72. Kong, Q., Ren, X., Jiang, L., et al. (2010), "Scirpusin A, a hydroxystilbene dimer
from Xinjiang wine grape, acts as an effective singlet oxygen quencher and DNA
damage protector", Journal of the Science of Food and Agriculture, 90(5), pp. 823-
828.
135
73. Kong, W.S., Xing, H.H., Li, J., et al. (2018), "Two new flavones from Cassia
pumila and their anti-tobacco mosaic virus activity", Chemistry of Natural
Compounds, 54(6), pp. 1048-1051.
74. Kshirsagar, A.D., Panchal, P.V., Harle, U.N., et al. (2014), "Anti-inflammatory
and antiarthritic activity of anthraquinone derivatives in rodents", International
Journal of Inflammation, 2014, p. 690596.
75. Kusano, R., Ogawa, S., Matsuo, Y., et al. (2011), "α-Amylase and Lipase
Inhibitory Activity and Structural Characterization of Acacia Bark
Proanthocyanidins", Journal of Natural Products, 74(2), pp. 119-128.
76. Kutil, Z., Kvasnicova, M., Temml, V., et al. (2014), "Effect of dietary stilbenes on
5-lipoxygenase and cyclooxygenases activities in vitro", International Journal of
Food Properties, 18, pp. 1471-1477.
77. Kyle, M.E., Miccadei, S., Nakae, D., et al. (1987), "Superoxide dismutase and
catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen",
Biochemical and Biophysical Research Communications, 149(3), pp. 889-896.
78. Lara-Ochoa, F., Sandoval-Minero, L.C., and Espinosa-Pérez, G. (2015), "A new
synthesis of resveratrol", Tetrahedron Letters, 56(44), pp. 5977-5979.
79. Lee, E.H., Park, K.I., Kim, K.Y., et al. (2019), "Liquiritigenin inhibits hepatic
fibrogenesis and TGF-β1/Smad with Hippo/YAP signal", Phytomedicine, 62, p.
152780.
80. Leu, S.J., Lin, Y.P., Lin, R.D., et al. (2006), "Phenolic constituents of Malus
doumeri var. formosana in the field of skin care", Biological and Pharmaceutical
Bulletin, 29(4), pp. 740-745.
81. Li, L., Ni, R., Shao, Y., et al. (2014), "Carrageenan and its applications in drug
delivery", Carbohydrate Polymers, 103, pp. 1-11.
82. Liang, F., Zhang, H., Gao, H., et al. (2021), "Liquiritigenin decreases
tumorigenesis by inhibiting DNMT activity and increasing BRCA1 transcriptional
activity in triple-negative breast cancer", Experimental Biology and Medicine,
246(4), pp. 459-466.
83. Lim, S.H. and Lee, J. (2012), "Methanol extract of Cassia mimosoides var.
nomame attenuates myocardial injury by inhibition of apoptosis in a rat model of
ischemia-reperfusion", Preventive Nutrition Food Science, 17(3), p. 177.
84. Lima, D.R.d., Franca, M.G.d.A., Oliveira, F.d.C.E.d., et al. (2022), "Metabolic
profiling and cytotoxic activity of methanol extracts from Chamaecrista duckeana
(P. Bezerra & A. Fern.) H. S. Irwin & Barheby (Leguminosae, Caesalpinioideae)",
Química nova, 45(7), pp. 803-806.
136
85. Lin, L.C., Pai, Y.F., and Tsai, T.H. (2015), "Isolation of luteolin and luteolin-7-O-
glucoside from Dendranthema morifolium Ramat Tzvel and their
pharmacokinetics in rats", Journal of Agricultural and Food Chemistry, 63(35),
pp. 7700-7706.
86. Lin, Y.P., Hsu, F.L., Chen, C.S., et al. (2007), "Constituents from the Formosan
apple reduce tyrosinase activity in human epidermal melanocytes",
Phytochemistry, 68(8), pp. 1189-1199.
87. Liu, D., Kim, D.H., Park, J.M., et al. (2009), "Piceatannol inhibits phorbol ester-
induced NF-kappa B activation and COX-2 expression in cultured human
mammary epithelial cells", Nutrition and Cancer, 61(6), pp. 855-863.
88. Liu, L., Li, J., Kundu, J.K., et al. (2014), "Piceatannol inhibits phorbol ester-
induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking
the activation of NF-κB and AP-1", Inflammation Research, 63(12), pp. 1013-
1021.
89. Maitreya, B.B. (2015), "Plant species of Cassia (sub-family Caesalpiniaceae) used
as herbal medicine in Bhavnagar area, Gujarat, India", International Journal of
Applied Research, 1(6), pp. 101-103.
90. Majeed, M., Nagabhushanam, K., Bhat, B., et al. (2022), "The anti-obesity
potential of Cyperus rotundus extract containing piceatannol, scirpusin A and
scirpusin B from rhizomes: preclinical and clinical evaluations", Diabetes,
Metabolic Syndrome and Obesity, 15, pp. 369-382.
91. Martinez, J. and Moreno, J.J. (2000), "Effect of resveratrol, a natural polyphenolic
compound, on reactive oxygen species and prostaglandin production",
Biochemical Pharmacology 59(7), pp. 865-870.
92. Mateos-Martín, M.L., Fuguet, E., Jiménez-Ardón, A., et al. (2014), "Identification
of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution
LC-ESI-MS/MS", Analytical and Bioanalytical Chemistry, 406(22), pp. 5501-
5506.
93. Meng, F.C. and Lin, J.K. (2019), "Liquiritigenin inhibits colorectal cancer
proliferation, invasion, and epithelial-to-mesenchymal transition by decreasing
expression of runt-related transcription factor 2", Oncology Research, 27(2), pp.
139-146.
94. Meselhy, M.R., Nakamura, N., and Hattori, M. (1997), "Biotransformation of (-)-
epicatechin 3-O-gallate by human intestinal bacteria", Chemical and
Pharmaceutical Bulletin, 45(5), pp. 888-893.
95. Mi, Q.-L., Kong, W.-S., Li, Y.-K., et al. (2021), "Chromone derivatives of Cassia
pumila and their anti-MRSA activity", Chemistry of Natural Compounds, 57(3),
pp. 432-435.
137
96. Moens, C., Muller, C.J.F., and Bouwens, L. (2022), "In vitro comparison of various
antioxidants and flavonoids from Rooibos as beta cell protectants against
lipotoxicity and oxidative stress-induced cell death", PLoS One, 17(5), p.
e0268551.
97. Morikawa, T., Xu, F., Matsuda, H., et al. (2010), "Structures of novel norstilbene
dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with
antiallergic and radical scavenging activities from Egyptian natural medicine
Cyperus longus", Chemical and Pharmaceutical Bulletin, 58(10), pp. 1379-1385.
98. Morimoto, S., Nonaka, G.-I., Chen, R.-F., et al. (1988), "Tannins and related
compounds. LXI. : Isolation and structures of novel bi- and triflavanoids from the
leaves of Cassia fistula L", Chemical and Pharmaceutical Bulletin, 36(1), pp. 39-
47.
99. Mukherjee, K.S., Bhattacharjee, P., Mukherjee, R.K., et al. (1987), "A new
anthraquinone pigment from Cassia mimosoides Linn.", Journal of the Indian
Chemical Society, 64(2), p. 130.
100. Nagoev, B.S., Abidov, M.T., and Ivanova, M.R. (2002), "LPO and free-radical
oxidation parameters in patients with acute viral hepatitis", Bulletin of
Experimental Biology and Medicine, 134(6), pp. 557-558.
101. Necas, J. and Bartosikova, L. (2013), "Carrageenan: A review", Veterinarni
Medicina, 58, pp. 187-205.
102. Nwafor, P.A. and Okwuasaba, F.K. (2001), "Effect of methanolic extract of Cassia
nigricans leaves on rat gastrointestinal tract", Fitoterapia, 72(3), pp. 206-214.
103. Obodozie, O.O., Okpako, L.C., Tarfa, F.D., et al. (2005), "Antiplasmodial
principles from Cassia nigricans", Pharmaceutical Biology, 42(8), pp. 626-628.
104. Pan, X., Kong, L.D., Zhang, Y., et al. (2000), "In vitro inhibition of rat monoamine
oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia
chinensis", Acta Pharmacologica Sinica, 21(10), pp. 949-953.
105. Panda, P.K., Patro, V.J., Mohanty, P.K., et al. (2011), "Antiulcer activity of Cassia
mimosoides bark extract and its comparison with ranitidine in Shay rat", Research
Journal of Pharmacognosy Phytochemistry, 3(4), pp. 166-168.
106. Patil, K.R., Mahajan, U.B., Unger, B.S., et al. (2019), "Animal models of
inflammation for screening of anti-inflammatory drugs: implications for the
discovery and development of phytopharmaceuticals", International Journal of
Molecular Sciences, 20(18), p. 4367.
107. Piotrowska, H., Kucinska, M., and Murias, M. (2012), "Biological activity of
piceatannol: Leaving the shadow of resveratrol", Mutation Research, 750(1), pp.
60-82.
138
108. Remsberg, C.M., Martinez, S.E., Akinwumi, B.C., et al. (2015), "Preclinical
pharmacokinetics and pharmacodynamics and content analysis of gnetol in
foodstuffs", Phytotherapy Research, 29(8), pp. 1168-1179.
109. Saito, C., Lemasters, J.J., and Jaeschke, H. (2010), "c-Jun N-terminal kinase
modulates oxidant stress and peroxynitrite formation independent of inducible
nitric oxide synthase in acetaminophen hepatotoxicity", Toxicology and Applied
Pharmacology, 246(1-2), pp. 8-17.
110. Shakibaei, M., Csaki, C., Nebrich, S., et al. (2008), "Resveratrol suppresses
interleukin-1beta-induced inflammatory signaling and apoptosis in human
articular chondrocytes: potential for use as a novel nutraceutical for the treatment
of osteoarthritis", Biochemical Pharmacology, 76(11), pp. 1426-1439.
111. Sharma, R. and Singh, D. (2012), "Phytochemical evaluation and quantification of
primary metabolites of Cassia pumila Lamk", International Journal of
Pharmaceutical Sciences Review and Research, 12(2), pp. 25-28.
112. Sharma, R.A., Bhardwaj, R., Sharma, P., et al. (2012), "Antimicrobial activity of
sennosides from Cassia pumila Lamk. ", Journal of Medicinal Plants Research,
6(19), pp. 3591-3595.
113. Singh, D., Sharma, S.K., Shekhawat, M., et al. (2012), "Screening of some
glycosidic flavonoids and their anti microbial activity of Cassia pumila Lamk.",
Asian Journal of Research in Chemistry, 5(2), pp. 305-311.
114. Spolarics, Z. and Meyenhofer, M. (2000), "Augmented resistance to oxidative
stress in fatty rat livers induced by a short-term sucrose-rich diet", Biochimica et
Biophysica Acta, 1487(2-3), pp. 190-200.
115. Subramanian, S.S. and Nagarajan, S. (1969), "Chemical examination of the leaves
of Cassia mimosoides", Indian Journal of Pharmacy and Pharmacology, 31(4),
pp. 110-113.
116. Subramanian, S.S. and Nagarajan, S. (1970), "Chemical components of the roots
and seeds of Cassia mimosoides", Indian Journal of Pharmacy and Pharmacology,
32(3), pp. 70-74.
117. Suresh, G., Tiwari, A.K., Radha Krishna Murthy, M., et al. (2012), "New advanced
glycation end-products inhibitors from Dichrostachys cinerea Wight & Arn",
Journal of Natural Medicines, 66(1), pp. 213-216.
118. Takada, Y., Noguchi, T., Okabe, T., et al. (1982), "Superoxide dismutase in various
tissues from rabbits bearing the Vx-2 carcinoma in the maxillary sinus", Cancer
Research, 42(10), pp. 4233-4235.
119. Takhtajan, A. (2009), Flowering Plants, Springer Netherlands.
139
120. Tangavelou, A.C., Viswanathan, M.B., Balakrishna, K., et al. (2018),
"Phytochemical analysis in the leaves of Chamaecrista nigricans (Leguminosae)",
Pharmaceutica Analytica Acta, 09(03), p. 1000582.
121. Tao, W., Dong, Y., Su, Q., et al. (2016), "Liquiritigenin reverses depression-like
behavior in unpredictable chronic mild stress-induced mice by regulating
PI3K/Akt/mTOR mediated BDNF/TrkB pathway", Behavioural Brain Research,
308, pp. 177-186.
122. Tarbeeva, D.V., Berdyshev, D.V., Pislyagin, E.A., et al. (2023), "Neuroprotective
and antiherpetic properties of polyphenolic compounds from Maackia amurensis
heartwood", Molecules, 28(6), p. 2593.
123. Thilagam, E., Parimaladevi, B., Kumarappan, C., et al. (2013), "α-Glucosidase and
α-amylase inhibitory activity of Senna surattensis", ournal of Acupuncture and
Meridian Studies, 6(1), pp. 24-30.
124. Tisserant, L.-P., Hubert, J., Lequart-Pillon, M., et al. (2016), "13C NMR and LC-
MS profiling of stilbenes from elicited grapevine hairy root cultures", Journal of
Natural Products, 79(11), pp. 2846-2855.
125. uz Cardona, M., Isabel Fernandez, M., Begon̄a Garcia, M., et al. (1986), "Synthesis
of natural polyhydroxystilbenes", Tetrahedron, 42(10), pp. 2725-2730.
126. van Meerloo, J., Kaspers, G.J., and Cloos, J. (2011), "Cell sensitivity assays: the
MTT assay", Methods Mol Biol, 731, pp. 237-45.
127. Vonia, S., Hartati, R., and Insanu, M. (2022), "In vitro alpha-glucosidase inhibitory
activity and the isolation of luteolin from the flower of Gymnanthemum
amygdalinum (Delile) Sch. Bip ex Walp", Molecules, 27(7).
128. Wang, J., Yang, R., Xiao, Z., et al. (2020), "Dihydrochalcones in Malus inhibit
bacterial growth by reducing cell membrane integrity", Food & Function, 11(7),
pp. 6517-6527.
129. Wang, L.Q., Meselhy, M.R., Li, Y., et al. (2001), "The heterocyclic ring fission
and dehydroxylation of catechins and related compounds by Eubacterium sp. strain
SDG-2, a human intestinal bacterium", Chemical and Pharmaceutical Bulletin,
49(12), pp. 1640-1643.
130. Wang, Z.B., Jiang, H., Xia, Y.G., et al. (2012), "α-Glucosidase inhibitory
constituents from Acanthopanax senticosus Harm leaves", Molecules, 17(6), pp.
6269-76.
131. Wasowicz, W., Nève, J., and Peretz, A. (1993), "Optimized steps in fluorometric
determination of thiobarbituric acid-reactive substances in serum: importance of
extraction pH and influence of sample preservation and storage", Clinical
Chemistry, 39(12), pp. 2522-2526.
140
132. Xiao, Z., Yang, R., Wang, H., et al. (2021), "Inhibitory properties of polyphenols
in Malus "Winter Red" crabapple fruit on α-glucosidase and α-amylase using
improved methods", Journal of Food Biochemistry, 45(10), p. e13942.
133. Xiao, Z., Zhang, Y., Chen, X., et al. (2017), "Extraction, identification, and
antioxidant and anticancer tests of seven dihydrochalcones from Malus 'Red
Splendor' fruit", Food Chemistry, 231, pp. 324-331.
134. Yahara, S., Ogata, T., Saijo, R., et al. (1989), "Isoflavan and related compounds
from Dalbergia odorifera. I", Chemical and Pharmaceutical Bulletin, 37(4), pp.
979-987.
135. Zhan, Y., Li, D., Wei, H., et al. (2000), "Emodin on hepatic fibrosis in rats",
Chinese Medical Journal, 113(7), pp. 599-601.
136. Zhang, A.J., Rimando, A.M., Mizuno, C.S., et al. (2017), "α-Glucosidase
inhibitory effect of resveratrol and piceatannol", The Journal of Nutritional
Biochemistry, 47, pp. 86-93.
137. Zhang, M., Xue, Y., Zheng, B., et al. (2021), "Liquiritigenin protects against
arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing
mTOR-mediated autophagy", Biomedicine & Pharmacotherapy, 143, p. 112167.
138. Zhang, Z., Wang, H., Kuang, Z., et al. (2023), "From tea to health: Exploring Abrus
mollis for liver protection and unraveling its potential mechanisms", Journal of
Agricultural and Food Chemistry 71(41), pp. 15145-15155.
139. Zhao, Y., Zhao, X., Guo, M., et al. (2023), "Stilbenoids and flavonoids from
Cajanus cajan (L.) Millsp. and their α-glucosidase inhibitory activities",
Molecules, 28(9), p. 3779.
140. Zhou, M., Zhou, K., Xiang, N.J., et al. (2015), "Flavones from Cassia siamea and
their anti-tobacco mosaic virus activity", Journal of Asian Natural Products
Research, 17(9), pp. 882-887.
141. Zhou, Q., Zhang, S., Geng, X., et al. (2022), "Antioxidant effects of roasted licorice
in a zebrafish model and its mechanisms", Molecules, 27(22), p. 7743.
142. Liao, L.M., Gao, Q., Li, Y.K., et al. (2020), "A new antimicrobial isobenzoisofuran
compound from Cassia pumila ", Zhongguo Zhong Yao Za Zhi, 45(4), pp. 896-898
(bản tóm tắt tiếng Anh).
143. Chamaecrista genus, accessed 15-8-2023, from www.theplantlist.org.
144. Flora of China 10 (2010), Science Press, China, accessed 14-8-2023, from
145. Flora of Taiwan checklist, accessed 15-8-2023, from