Luận án Nghiên cứu thay đổi huyết động và hiệu quả của điều trị theo đích ở bệnh nhân cao tuổi được gây tê tuỷ sống cho phẫu thuật thay khớp háng

of age on 6-month survival in patients with cardiovascular risk factors undergoing elective non-cardiac surgery. Int J Clin Pract. 2007;61(5):768-776. doi:10.1111/j.1742-1241.2007.01304.x 28. Công Quyết Thắng. Gây tê tủy sống, ngoài màng cứng. In: Vol 2. Nhà xuất bản Y Học; 2002:44-83. 29. Brown DL, Miller RD. Spinal, Epidural and Caudal Anesthesia. In: Miller’s Anesthesia. Vol 1. Seventh. Churchill Livingstone Elsevier; :1611-1638. 30. McDonald SB, Liu SS, Kopacz DJ, Stephenson CA. Hyperbaric spinal ropivacaine: a comparison to bupivacaine in volunteers. Anesthesiology. 1999;90(4):971-977. doi:10.1097/00000542-199904000-00007 31. Gautier PE, De Kock M, Van Steenberge A, et al. Intrathecal ropivacaine for ambulatory surgery. Anesthesiology. 1999;91(5):1239-1245. doi:10.1097/ 00000542-199911000-00013 32. Alley EA, Kopacz DJ, McDonald SB, Liu SS. Hyperbaric spinal levobupivacaine: a comparison to racemic bupivacaine in volunteers. Anesth Analg. 2002;94(1):188-193, table of contents. doi:10.1097/00000539- 200201000-00036 33. Glaser C, Marhofer P, Zimpfer G, et al. Levobupivacaine versus racemic bupivacaine for spinal anesthesia. Anesth Analg. 2002;94(1):194-198, table of contents. doi:10.1097/00000539-200201000-00037 34. Butterworth J. Physiology of spinal anesthesia: what are the implications for management? Reg Anesth Pain Med. 1998;23(4):370-373; discussion 384-387. doi:10.1016/s1098-7339(98)90008-6 35. Crystal GJ, Salem MR. The Bainbridge and the “reverse” Bainbridge reflexes: history, physiology, and clinical relevance. Anesth Analg. 2012;114(3):520- 532. doi:10.1213/ANE.0b013e3182312e21 36. Fitzgerald JP, Fedoruk KA, Jadin SM, Carvalho B, Halpern SH. Prevention of hypotension after spinal anaesthesia for caesarean section: a systematic review and network meta-analysis of randomised controlled trials. Anaesthesia. 2020;75(1):109-121. doi:10.1111/anae.14841 37. Langesæter E, Dyer RA. Maternal haemodynamic changes during spinal anaesthesia for caesarean section. Curr Opin Anaesthesiol. 2011;24(3):242- 248. doi:10.1097/ACO.0b013e32834588c5 38. Salinas FV, Sueda LA, Liu SS. Physiology of spinal anaesthesia and practical suggestions for successful spinal anaesthesia. Best Pract Res Clin Anaesthesiol. 2003;17(3):289-303. doi:10.1016/s1521-6896(02)00114-3 39. Hanss R, Bein B, Weseloh H, et al. Heart rate variability predicts severe hypotension after spinal anesthesia. Anesthesiology. 2006;104(3):537-545. doi:10.1097/00000542-200603000-00022 40. Meyhoff CS, Haarmark C, Kanters JK, Rasmussen LS. Is it possible to predict hypotension during onset of spinal anesthesia in elderly patients? J Clin Anesth. 2009;21(1):23-29. doi:10.1016/j.jclinane.2008.06.015 41. Ripollés Melchor J, Espinosa Á, Martínez Hurtado E, et al. Colloids versus crystalloids in the prevention of hypotension induced by spinal anesthesia in elective cesarean section. A systematic review and meta-analysis. Minerva Anestesiol. 2015;81(9):1019-1030. 42. Banerjee A, Stocche RM, Angle P, Halpern SH. Preload or coload for spinal anesthesia for elective Cesarean delivery: a meta-analysis. Can J Anaesth. 2010;57(1):24-31. doi:10.1007/s12630-009-9206-7 43. Biboulet P, Jourdan A, Van Haevre V, et al. Hemodynamic profile of target- controlled spinal anesthesia compared with 2 target-controlled general anesthesia techniques in elderly patients with cardiac comorbidities. Reg Anesth Pain Med. 2012;37(4):433-440. doi:10.1097/AAP.0b013e318252e901 44. Minville V, Fourcade O, Grousset D, et al. Spinal anesthesia using single injection small-dose bupivacaine versus continuous catheter injection techniques for surgical repair of hip fracture in elderly patients. Anesth Analg. 2006;102(5):1559-1563. doi:10.1213/01.ane.0000218421.18723.cf 45. Nakasuji M, Suh SH, Nomura M, et al. Hypotension from spinal anesthesia in patients aged greater than 80 years is due to a decrease in systemic vascular resistance. J Clin Anesth. 2012;24(3):201-206. doi:10.1016/j.jclinane.2011.07.014 46. Wesselink EM, Kappen TH, Torn HM, Slooter AJC, van Klei WA. Intraoperative hypotension and the risk of postoperative adverse outcomes: a systematic review. Br J Anaesth. 2018;121(4):706-721. doi:10.1016/ j.bja.2018.04.036 47. KlÖHR S, Roth R, Hofmann T, Rossaint R, Heesen M. Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturients. Acta Anaesthesiologica Scandinavica. 2010; 54(8):909-921. doi:10.1111/j.1399-6576.2010.02239.x 48. Walsh M, Devereaux PJ, Garg AX, et al. Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery. Anesthesiology. 2013;119(3):507-515. doi:10.1097/ALN.0b013e3182a10e26 49. Maheshwari K, Khanna S, Bajracharya GR, et al. A Randomized Trial of Continuous Noninvasive Blood Pressure Monitoring During Noncardiac Surgery. Anesth Analg. 2018;127(2):424-431. doi:10.1213/ ANE.0000000000003482 50. Salmasi V, Mascha EJ. Relationship between Intraoperative Hypotension, Defined by Either Reduction from Baseline or Absolute Thresholds, and Acute Kidney and Myocardial Injury after Noncardiac Surgery. PERIOPERATIVE MEDICINE.:19. 51. Griffiths R, Beech F, Brown A, et al. Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia. 2014;69 Suppl 1:81-98. doi:10.1111/anae.12524 52. White SM, Moppett IK, Griffiths R, et al. Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2). Anaesthesia. 2016;71(5):506-514. doi:10.1111/anae.13415 53. Futier E, Lefrant JY, Guinot PG, et al. Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery. JAMA. 2017; 318(14):1346-1357. doi:10.1001/jama.2017.14172 54. van den Bekerom MPJ, Hilverdink EF, Sierevelt IN, et al. A comparison of hemiarthroplasty with total hip replacement for displaced intracapsular fracture of the femoral neck: a randomised controlled multicentre trial in patients aged 70 years and over. J Bone Joint Surg Br. 2010;92(10):1422-1428. doi:10.1302/0301-620X.92B10.24899 55. Dương ĐT. Kết quả phẫu thay khớp háng bán phần điều trị gãy liên mấu chuyển xương đùi ở người cao tuổi. VMJ. 2021;505(1). doi:10.51298/ vmj. v505i1.1031 56. Vũ Trường Thịnh, Trần Minh Long Triều, Nguyễn Xuân Thùy. Mô tả đặc điểm và đánh giá kết quả thay khớp háng bán phần chuôi dài không xi măng ở bệnh nhân cao tuổi gãy liên mấu chuyển xương đùi tại bệnh viện Việt Đức. Tạp chí nghiên cứu y học. 2022;153(3):42-52. 57. Avery PP, Baker RP, Walton MJ, et al. Total hip replacement and hemiarthroplasty in mobile, independent patients with a displaced intracapsular fracture of the femoral neck: A Seven- To Ten-Year Follow-Up Report Of A Prospective Randomised Controlled Trial. The Journal of Bone & Joint Surgery British Volume. 2011;93-B(8):1045-1048. doi:10.1302/0301- 620X.93B8.27132 58. Parker MJ, Handoll HHG, Griffiths R. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2004;(4):CD000521. doi:10.1002/ 14651858.CD000521.pub2 59. Neuman MD, Rosenbaum PR, Ludwig JM, Zubizarreta JR, Silber JH. Anesthesia technique, mortality, and length of stay after hip fracture surgery. JAMA. 2014;311(24):2508-2517. doi:10.1001/jama.2014.6499 60. Guay J, Choi P, Suresh S, Albert N, Kopp S, Pace NL. Neuraxial blockade for the prevention of postoperative mortality and major morbidity: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2014; 2014(1): CD010108. doi:10.1002/14651858.CD010108.pub2 61. Nishimori M, Low JH, Zheng H, Ballantyne JC. Epidural pain relief versus systemic opioid-based pain relief for abdominal aortic surgery. In: The Cochrane Collaboration, ed. Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd; 2012:CD005059.pub3. doi:10.1002/ 14651858.CD005059.pub3 62. Guay J. The benefits of adding epidural analgesia to general anesthesia: a metaanalysis. J Anesth. 2006;20(4):335-340. doi:10.1007/s00540-006-0423-8 63. Guay J. The effect of neuraxial blocks on surgical blood loss and blood transfusion requirements: a meta-analysis. Journal of Clinical Anesthesia. 2006;18(2):124-128. doi:10.1016/j.jclinane.2005.08.013 64. Chang CC, Lin HC, Lin HW, Lin HC. Anesthetic Management and Surgical Site Infections in Total Hip or Knee Replacement: A Population-based Study. Anesthesiology. 2010;113(2):279-284. doi:10.1097/ALN.0b013e3181e2c1c3 65. Guay J, Parker MJ, Gajendragadkar PR, Kopp S. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2016;2016(2):CD000521. doi:10.1002/14651858.CD000521.pub3 66. Guay J, Parker MJ, Griffiths R, Kopp SL. Peripheral Nerve Blocks for Hip Fractures: A Cochrane Review. Anesth Analg. 2018;126(5):1695-1704. doi:10.1213/ANE.0000000000002489 67. Dangle J, Kukreja P, Kalagara H. Review of Current Practices of Peripheral Nerve Blocks for Hip Fracture and Surgery. Curr Anesthesiol Rep. 2020;10(3):259-266. doi:10.1007/s40140-020-00393-7 68. Taha A, Ghoneim M. Hip hemiarthroplasty using major lower limb nerve blocks: A preliminary report of a case series. Saudi journal of anaesthesia. 2014;8:355-358. doi:10.4103/1658-354X.136432 69. Bhandari M, Devereaux PJ, Tornetta P, et al. Operative management of displaced femoral neck fractures in elderly patients. An international survey. J Bone Joint Surg Am. 2005;87(9):2122-2130. doi:10.2106/JBJS.E.00535 70. Van den Bekerom MPJ, Sierevelt IN, Bonke H, Raaymakers ELFB. The natural history of the hemiarthroplasty for displaced intracapsular femoral neck fractures. Acta Orthop. 2013;84(6):555-560. doi:10.3109/ 17453674.2013.867763 71. Liodakis E, Antoniou J, Zukor DJ, Huk OL, Epure LM, Bergeron SG. Major Complications and Transfusion Rates After Hemiarthroplasty and Total Hip Arthroplasty for Femoral Neck Fractures. The Journal of Arthroplasty. 2016; 31(9):2008-2012. doi:10.1016/j.arth.2016.02.019 72. Kamiloski V, Kasapinova K. Analysis of the Hemoglobin Level Drop in Patients with Hip Fracture After Admission. Acta Clin Croat. 2017;56(4):645- 649. doi:10.20471/acc.2017.56.04.10 73. Swain DG, Nightingale PG, Patel JV. Blood transfusion requirements in femoral neck fracture. Injury. 2000;31(1):7-10. doi:10.1016/s0020-1383(99)00191-6 74. Lee C, Freeman R, Edmondson M, Rogers BA. The efficacy of tranexamic acid in hip hemiarthroplasty surgery: an observational cohort study. Injury. 2015;46(10):1978-1982. doi:10.1016/j.injury.2015.06.039 75. Verlicchi F, Desalvo F, Zanotti G, Morotti L, Tomasini I. Red cell transfusion in orthopaedic surgery: a benchmark study performed combining data from different data sources. Blood Transfus. 2011;9(4):383-387. doi:10.2450/ 2011.0095-10 76. Wang JQ, Chen LY, Jiang BJ, Zhao YM. Development of a Nomogram for Predicting Blood Transfusion Risk After Hemiarthroplasty for Femoral Neck Fractures in Elderly Patients. Med Sci Monit. 2020;26:e920255-1-e920255-7. doi:10.12659/MSM.920255 77. Gu WJ, Gu XP, Wu XD, et al. Restrictive Versus Liberal Strategy for Red Blood-Cell Transfusion: A Systematic Review and Meta-Analysis in Orthopaedic Patients. The Journal of Bone and Joint Surgery. 2018; 100(8):686-695. doi:10.2106/JBJS.17.00375 78. D’Amore T, Loewen M, Gorczyca MT, et al. Rethinking strategies for blood transfusion in hip fracture patients. OTA Int. 2020;3(3):e083. doi:10.1097/ OI9.0000000000000083 79. Nguyễn Thụ. Lưu lượng tim. In: Bài Giảng Gây Mê Hồi Sức. Vol 1. Nhà xuất bản Y Học; 2006:52-63. 80. Vella C, Robergs R. A review of the stroke volume response to upright exercise in healthy subjects. Br J Sports Med. 2005;39(4):190-195. doi:10.1136/bjsm.2004.013037 81. Kobe J, Mishra N, Arya VK, Al-Moustadi W, Nates W, Kumar B. Cardiac Output Monitoring: Technology and Choice. Ann Card Anaesth. 2019;22(1):6- 17. doi:10.4103/aca.ACA_41_18 82. Drummond KE, Murphy E. Minimally invasive cardiac output monitors. Continuing Education in Anaesthesia Critical Care & Pain. 2012;12(1):5-10. doi:10.1093/bjaceaccp/mkr044 83. Mehta Y, Arora D. Newer methods of cardiac output monitoring. World J Cardiol. 2014;6(9):1022-1029. doi:10.4330/wjc.v6.i9.1022 84. Saugel B, Vincent JL. Cardiac output monitoring: how to choose the optimal method for the individual patient. Curr Opin Crit Care. 2018;24(3):165-172. doi:10.1097/MCC.0000000000000492 85. Wan L, Naka T, Uchino S, Bellomo R. A pilot study of pulse contour cardiac output monitoring in patients with septic shock. Crit Care Resusc. 2005;7(3):165. 86. Marik PE. Noninvasive cardiac output monitors: a state-of the-art review. J Cardiothorac Vasc Anesth. 2013;27(1):121-134. doi:10.1053/ j.jvca. 2012.03.022 87. Slagt C, Malagon I, Groeneveld ABJ. Systematic review of uncalibrated arterial pressure waveform analysis to determine cardiac output and stroke volume variation. British Journal of Anaesthesia. 2014;112(4):626-637. doi:10.1093/bja/aet429 88. Nguyễn Thị Thúy Ngân. Đánh giá vai trò theo dõi huyết động của phƣơng pháp siêu âm không xâm lấn (USCOM) ở bệnh nhân sốc nhiễm trùng. Luận văn tiến sỹ y học. Published online 2020. 89. Ghisi D, Garroni M, Giannone S, et al. Non-invasive haemodynamic monitoring with Clearsight in patients undergoing spinal anaesthesia for total hip replacement. A prospective observational cohort study. Acta Biomed. 2020; 91(4):e2020182. doi:10.23750/abm.v91i4.8665 90. Nguyễn Quốc Kính, Ngô Đức Tuấn. So Sánh Hiệu Quả Ồn Định Huyết Áp Của Truyền Dịch Trước và Trong Lúc Làm Thủ Thuật Gây Tê Tủy Sống. Trường Đại học Y Hà Nội; 2016. 91. Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS. Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients. CHEST. 1988;94(6):1176-1186. doi:10.1378/chest.94.6.1176 92. Chong MA, Wang Y, Berbenetz NM, McConachie I. Does goal-directed haemodynamic and fluid therapy improve peri-operative outcomes?: A systematic review and meta-analysis. European Journal of Anaesthesiology | EJA. 2018;35(7):469-483. doi:10.1097/EJA.0000000000000778 93. Saugel B, Cecconi M, Wagner JY, Reuter DA. Noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine. British Journal of Anaesthesia. 2015;114(4):562-575. doi:10.1093/bja/aeu447 94. Feng S, Yang S, Xiao W, Wang X, Yang K, Wang T. Effects of perioperative goal-directed fluid therapy combined with the application of alpha-1 adrenergic agonists on postoperative outcomes: a systematic review and meta-analysis. BMC Anesthesiol. 2018;18:113. doi:10.1186/s12871-018-0564-y 95. Wang P, Wang HW, Zhong TD. Effect of stroke volume variability- guided intraoperative fluid restriction on gastrointestinal functional recovery. Hepatogastroenterology. 2012;59(120):2457-2460. doi:10.5754/hge12283 96. Sinclair S, James S, Singer M. Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. BMJ. 1997;315(7113):909-912. doi:10.1136/bmj.315.7113.909 97. Moppett IK, Rowlands M, Mannings A, Moran CG, Wiles MD, NOTTS Investigators. LiDCO-based fluid management in patients undergoing hip fracture surgery under spinal anaesthesia: a randomized trial and systematic review. Br J Anaesth. 2015;114(3):444-459. doi:10.1093/bja/aeu386 98. Lewis SR, Butler AR, Brammar A, Nicholson A, Smith AF. Perioperative fluid volume optimization following proximal femoral fracture. Cochrane Database Syst Rev. 2016;2016(3):CD003004. doi:10.1002/14651858.CD003004.pub4 99. Bartha E, Arfwedson C, Imnell A, Fernlund ME, Andersson LE, Kalman S. Randomized controlled trial of goal-directed haemodynamic treatment in patients with proximal femoral fracture. British Journal of Anaesthesia. 2013;110(4):545-553. doi:10.1093/bja/aes468 100. Venn R, Steele A, Richardson P, Poloniecki J, Grounds M, Newman P. Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures†. British Journal of Anaesthesia. 2002;88(1):65-71. doi:10.1093/bja/88.1.65 101. Lưu Ngọc Hoạt, và cộng sự. Phương Pháp Nghiên Cứu Khoa Học Trong y Học và Sức Khỏe Cộng Đồng. Trường Đại học Y Hà Nội; 2006. 102. Cops J. Hypotension. NYSORA. Published December 15, 2022. Accessed September 23, 2023. https://www.nysora.com/anesthesia/hypotension/ 103. Normal hemodynamic parameters and laboratory values. Edwards Lifesciences. Accessed October 13, 2023. https://education.edwards.com/normal- hemodynamic-parameters-pocket-card/1167897 104. Davies SJ, Yates DR, Wilson RJT, et al. A randomised trial of non-invasive cardiac output monitoring to guide haemodynamic optimisation in high risk patients undergoing urgent surgical repair of proximal femoral fractures (ClearNOF trial NCT02382185). Perioper Med (Lond). 2019;8:8. doi:10.1186/s13741-019-0119-x 105. Schofield I, Stott DJ, Tolson D, McFadyen A, Monaghan J, Nelson D. Screening for cognitive impairment in older people attending accident and emergency using the 4-item Abbreviated Mental Test. Eur J Emerg Med. 2010;17(6):340-342. doi:10.1097/MEJ.0b013e32833777ab 106. Trần Đỗ Trinh, Trần Văn Đồng. Hướng Dẫn Đọc Điện Tim. Nhà xuất bản Y Học; 2014. 107. Nguyễn Hữu Tú HT. Dự phòng và chống đau sau mổ. In: Gây Mê Hồi Sức. Nhà xuất bản Y Học; 2014:311-324. 108. Công Quyết Thắng. Gây tê tủy sống. In: Gây Mê Hồi Sức. Nhà xuất bản Y Học; 2014:265-277. 109. Sullivan KJ. Demographic factors in hip fracture incidence and mortality rates in California, 2000–2011. Published online 2016:10. 110. Alswat KA. Gender Disparities in Osteoporosis. J Clin Med Res. 2017;9(5):382-387. doi:10.14740/jocmr2970w 111. Macdonald HM, Nishiyama KK, Kang J, Hanley DA, Boyd SK. Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study. J Bone Miner Res. 2011;26(1):50- 62. doi:10.1002/jbmr.171 112. Park HJ, Kang H, Lee JW, Baek SM, Seo JS. Comparison of hemodynamic changes between old and very old patients undergoing cemented bipolar hemiarthroplasty under spinal anesthesia. Korean J Anesthesiol. 2015;68(1):37-42. doi:10.4097/kjae.2015.68.1.37 113. Buggy D, Higgins P, Moran C, O’Brien D, O’Donovan F, McCarroll M. Prevention of Spinal Anesthesia-Induced Hypotension in the Elderly: Comparison Between Preanesthetic Administration of Crystalloids, Colloids, and No Prehydration. ANESTH ANALG. 1997;84:106-110. 114. Olofsson C, Nygards EB, Bjersten AB, Hessling A. Low-dose bupivacaine with sufentanil prevents hypotension after spinal anesthesia for hip repair in elderly patients. Acta Anaesthesiol Scand. 2004;48(10):1240-1244. doi:10.1111/j.1399-6576.2004.00504.x 115. Zorko N, Kamenik M, Starc V. The Effect of Trendelenburg Position, Lactated Ringer’s Solution and 6% Hydroxyethyl Starch Solution on Cardiac Output After Spinal Anesthesia. Anesthesia & Analgesia. 2009;108(2):655-659. doi:10.1213/ane.0b013e31818ec9e5 116. Đỗ Bích Diệp, Hoàng Trung Vinh, Đinh Gia Huệ. Thực trạng trầm cảm và một số yếu tố liên quan ở người bệnh đái tháo đường tại bệnh viện Nội tiết Trung ương năm 2022. Tạp Chí Y học Việt Nam. 525(1B). 117. Ben-David B, Frankel R, Arzumonov T, Marchevsky Y, Volpin G. Minidose Bupivacaine–Fentanyl Spinal Anesthesia for Surgical Repair of Hip Fracture in the Aged. Anesthesiology. 2000;92(1):6. doi:10.1097/00000542-200001000-00007 118. Favarel-Garrigues JF, Sztark F, Petitjean ME, Thicoipe M, Lassie P, Dabadie P. Hemodynamic Effects of Spinal Anesthesia in the Elderly: Single Dose Versus Titration Through a Catheter. Anesthesia & Analgesia. 1996;82(2):312- 316. doi:10.1097/00000539-199602000-00017 119. Mercier FJ, Augè M, Hoffmann C, Fischer C, Le Gouez A. Maternal hypotension during spinal anesthesia for caesarean delivery. Minerva Anestesiol. 2013;79(1):62-73. 120. Ripollés-Melchor J, Casans-Francés R, Espinosa A, et al. Goal directed hemodynamic therapy based in esophageal Doppler flow parameters: A systematic review, meta-analysis and trial sequential analysis. Rev Esp Anestesiol Reanim. 2016;63(7):384-405. doi:10.1016/j.redar.2015.07.009 121. Kamenik M, Paver-Eržen V. The Effects of Lactated Ringer’s Solution Infusion on Cardiac Output Changes After Spinal Anesthesia: Anesthesia & Analgesia. 2001;92(3):710-714. doi:10.1097/00000539-200103000-00030 122. Žunić M, Krčevski Škvarč N, Kamenik M. The influence of the infusion of ephedrine and phenylephrine on the hemodynamic stability after subarachnoid anesthesia in senior adults - a controlled randomized trial. BMC Anesthesiology. 2019;19(1):207. doi:10.1186/s12871-019-0878-4 123. Xie R, Wang L, Bao H. Crystalloid and colloid preload for maintaining cardiac output in elderly patients undergoing total hip replacement under spinal anesthesia. J Biomed Res. 2011;25(3):185-190. doi:10.1016/S1674- 8301(11)60024-9 124. Langesæter E, Rosseland LA, Stubhaug A. Continuous Invasive Blood Pressure and Cardiac Output Monitoring during Cesarean Delivery: A Randomized, Double-blind Comparison of Low-dose versusHigh-dose Spinal Anesthesia with Intravenous Phenylephrine or Placebo Infusion. Anesthesiology. 2008;109(5):856-863. doi:10.1097/ALN.0b013e31818a401f 125. Dyer RA, Reed AR, van Dyk D, et al. Hemodynamic Effects of Ephedrine, Phenylephrine, and the Coadministration of Phenylephrine with Oxytocin during Spinal Anesthesia for Elective Cesarean Delivery. Anesthesiology. 2009;111(4):753-765. doi:10.1097/ALN.0b013e3181b437e0 126. Donati A, Mercuri G, Iuorio S, et al. Haemodynamic modifications after unilateral subarachnoid anaesthesia evaluated with transthoracic echocardiography. Minerva Anestesiol. 2005;71(3):75-81. 127. Hofhuizen C, Lemson J, Snoeck M, Scheffer GJ. Spinal anesthesia-induced hypotension is caused by a decrease in stroke volume in elderly patients. Local Reg Anesth. 2019;12:19-26. doi:10.2147/LRA.S193925 128. Errando CL, Peiró CM, Gimeno A, Soriano JL. Single shot spinal anesthesia with very low hyperbaric bupivacaine dose (3.75 mg) for hip fracture repair surgery in the elderly. A randomized, double blinded study. Rev Esp Anestesiol Reanim. 2014;61(9):481-488. doi:10.1016/j.redar.2014.02.004 129. Lairez O, Ferré F, Portet N, et al. Cardiovascular effects of low-dose spinal anaesthesia as a function of age: An observational study using echocardiography. Anaesth Crit Care Pain Med. 2015;34(5):271-276. doi:10.1016/j.accpm.2015.02.007 130. Rooke GA, Freund PR, Jacobson AF. Hemodynamic response and change in organ blood volume during spinal anesthesia in elderly men with cardiac disease. Anesth Analg. 1997;85(1):99-105. doi:10.1097/00000539-199707000-00018 131. Meyhoff CS, Hesselbjerg L, Koscielniak-Nielsen Z, Rasmussen LS. Biphasic cardiac output changes during onset of spinal anaesthesia in elderly patients: European Journal of Anaesthesiology. 2007;24(9):770-775. doi:10.1017/ S0265021507000427 132. Riesmeier A, Schellhaass A, Boldt J, Suttner S. Crystalloid/colloid versus crystalloid intravascular volume administration before spinal anesthesia in elderly patients: the influence on cardiac output and stroke volume. Anesth Analg. 2009;108(2):650-654. doi:10.1213/ane.0b013e3181923722 133. Asehnoune K, Larousse E, Tadié JM, Minville V, Droupy S, Benhamou D. Small-dose bupivacaine-sufentanil prevents cardiac output modifications after spinal anesthesia. Anesth Analg. 2005;101(5):1512-1515. doi:10.1213/ 01.ANE.0000180996.91358.CC 134. Rout CC, Rocke DA, Levin J, Gouws E, Reddy D. A reevaluation of the role of crystalloid preload in the prevention of hypotension associated with spinal anesthesia for elective cesarean section. Anesthesiology. 1993;79(2):262-269. doi:10.1097/00000542-199308000-00011 135. Jackson R, Reid JA, Thorburn J. Volume preloading is not essential to prevent spinal-induced hypotension at caesarean section. Br J Anaesth. 1995; 75(3):262-265. doi:10.1093/bja/75.3.262 136. Pouta AM, Karinen J, Vuolteenaho OJ, Laatikainen TJ. Effect of intravenous fluid preload on vasoactive peptide secretion during Caesarean section under spinal anaesthesia. Anaesthesia. 1996;51(2):128-132. doi:10.1111/j.1365- 2044.1996.tb07698.x 137. Ewaldsson CA, Hahn RG. Volume kinetics of Ringer’s solution during induction of spinal and general anaesthesia. Br J Anaesth. 2001;87(3):406-414. doi:10.1093/bja/87.3.406 138. Dyer RA, Farina Z, Joubert IA, et al. Crystalloid preload versus rapid crystalloid administration after induction of spinal anaesthesia (coload) for elective caesarean section. Anaesth Intensive Care. 2004;32(3):351-357. doi:10.1177/0310057X0403200308 139. Mercier FJ, Diemunsch P, Ducloy-Bouthors AS, et al. 6% Hydroxyethyl starch (130/0.4) vs Ringer’s lactate preloading before spinal anaesthesia for Caesarean delivery: the randomized, double-blind, multicentre CAESAR trial. Br J Anaesth. 2014;113(3):459-467. doi:10.1093/bja/aeu103 140. Myburgh JA, Mythen MG. Resuscitation fluids. N Engl J Med. 2013; 369(13):1243-1251. doi:10.1056/NEJMra1208627 141. Elewa G, Labib H, Samir G. Comparison between colloid preload, coload, and no load in the prevention of spinal anesthesia-induced hypotension in patients undergoing inguinal hernia repair. Ain-Shams J Anaesthesiol. 2016;9(2):250. doi:10.4103/1687-7934.182266 142. Nagra NS, van Popta D, Whiteside S, Holt EM. An analysis of postoperative hemoglobin levels in patients with a fractured neck of femur. Acta Orthop Traumatol Turc. 2016;50(5):507-513. doi:10.1016/j.aott.2015.11.001 143. Testa G, Montemagno M, Vescio A, et al. Blood-Transfusion Risk Factors after Intramedullary Nailing for Extracapsular Femoral Neck Fracture in Elderly Patients. J Funct Morphol Kinesiol. 2023;8(1):27. doi:10.3390/ jfmk8010027 144. Habib AS. A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia. Anesth Analg. 2012;114(2):377-390. doi:10.1213/ANE.0b013e3182373a3e 145. Coe AJ, Revanäs B. Is crystalloid preloading useful in spinal anaesthesia in the elderly? Anaesthesia. 1990;45(3):241-243. doi:10.1111/j.1365- 2044.1990.tb14696.x 146. Critchley LA, Stuart JC, Short TG, Gin T. Haemodynamic effects of subarachnoid block in elderly patients. Br J Anaesth. 1994;73(4):464-470. doi:10.1093/bja/73.4.464 147. Tamilselvan P, Fernando R, Bray J, Sodhi M, Columb M. The effects of crystalloid and colloid preload on cardiac output in the parturient undergoing planned cesarean delivery under spinal anesthesia: a randomized trial. Anesth Analg. 2009;109(6):1916-1921. doi:10.1213/ANE.0b013e3181bbfdf6 148. Ogata K, Fukusaki M, Miyako M, Tamura S, Kanaide M, Sumikawa K. [The effects of colloid preload on hemodynamics and plasma concentration of atrial natriuretic peptide during spinal anesthesia in elderly patients]. Masui. 2003; 52(1):20-25. 149. Yu M, Burchell S, Hasaniya NW, Takanishi DM, Myers SA, Takiguchi SA. Relationship of mortality to increasing oxygen delivery in patients > or = 50 years of age: a prospective, randomized trial. Crit Care Med. 1998;26(6):1011- 1019. doi:10.1097/00003246-199806000-00018 150. Pearse RM, Harrison DA, MacDonald N, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014;311(21):2181-2190. doi:10.1001/jama.2014.5305 151. Alghanem SM, Massad IM, Almustafa MM, et al. Relationship between intra- operative hypotension and post-operative complications in traumatic hip surgery. Indian J Anaesth. 2020;64(1):18-23. doi:10.4103/ija.IJA_397_19 152. Ryan DJ, Yoshihara H, Yoneoka D, Egol KA, Zuckerman JD. Delay in Hip Fracture Surgery: An Analysis of Patient-Specific and Hospital-Specific Risk Factors. Journal of Orthopaedic Trauma. 2015;29(8):343-348. doi:10.1097/ BOT.0000000000000313 BỆNH ÁN NGHIÊN CỨU Nhóm: 1 2 I. Hành chính Họ và tên: Tuổi: Nam / Nữ Nghề nghiệp: Địa chỉ: Số điện thoại: Ngày vào viện Ngày PT Ngày ra viện II.Khám BN trước phẫu thuật 1. Tiền sử THA Điều trị thường xuyên ĐTĐ TBMMN Suy thận COPD 2. Chiều cao cm 3. Cân nặng kg III.Trong phẫu thuật Thời gian bắt đầu tê TS : Thời gian bắt đầu PT : Thời gian kết thúc PT : Thời gian ra hồi tỉnh : TỔNG Trước phẫu thuật + HCK : Trong phẫu thuật + Dịch keo : + Dịch tinh thể : + HCK (trong PT) : HCK (sau PT): + Ephedrin : (mg) + Dobutamine : (mcg) Note Time CO CI SV SVR SVRI DO2 DO2I SBP/DBP/MAP/HR CVP Hb Ephedrin Dịch keo Dịch TT HCK Ghi chú T0 T250 T1 T5 T10 T15 T20 T25 T30 Tend KM pH PaCO2 PaCO2 SaO2 HCO3 BE Hb Lactat P/F T0 T250 T1 T10 T20 T30 Tend Tổng kết số lần đã thực hiện/đạt đích trong phẫu thuật: - Số lần bolus Gelofusin: - Số lần đạt đích MAP/SVI sau bolus Gelofusin: - Số lần bolus Ephedrin: - Số lần đạt đích sau bolus Ephedrin: IV. Sau phẫu thuật 1. Biến chứng sau mổ Tim mạch : Hô hấp : Thận : Nhiễm trùng vết mổ : Xuất huyết tiêu hóa : Loạn thần : Tụ máu sau mổ : 2. Tổng kết thời gian Thời gian nằm viện: Thời gian SM-RV: Thời gian sống sau PT: