Luận án Nghiên cứu nồng độ lipoprotein-Associated phospholipase A2 và kiểu hình của lipoprotein tỷ trọng thấp ở bệnh nhân hội chứng mạch vành cấp

Tăng huyết áp là một nguy cơ chính, độc lập của BĐMV, mặc dù tăng huyết áp dường như là nguy cơ thúc đẩy XVĐM phụ thuộc cholesterol [2]. Chúng tôi thấy rằng ở đối tượng HCMVC tỷ lệ tăng huyết áp là 54% (bảng 3.5). Tỷ lệ tăng huyết áp thay đổi khá nhiều giữa các nghiên cứu khác nhau như Wolfgang Koenig và CS [111] là 55%, kết quả này tương tự chúng tôi, Blankenberg. S và CS [41] là 75% và Lương Thị Kim Liên [9] là 81%, cao hơn chúng tôi. Tỷ lệ tăng huyết áp của chúng tôi thấp hơn so với một số nghiên cứu là do chúng tôi đã loại các bệnh nhân có dùng thuốc ảnh hưởng đến nồng độ lipid máu. Nhìn chung tất cả các nghiên cứu đều có một tỷ lệ tăng huyết áp chiếm đa số

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Zeymer U, Arntz HR, Mark B, et al (2012), ―Efficacy and safety of a high loading dose of clopidogrel administered prehospitally to improve primary percutaneous coronary intervention in acute myocardial infarction: the randomized CIPAMI trial‖, Clinical Research in Cardiology, 101, pp. 305- 312. Phụ lục 1: PHIẾU THÔNG TIN NGHIÊN CỨU Đề tài: Nghiên cứu Lp-PLA2 và kiểu hình LDL ở bệnh nhân HCMVC 1/ Hành chánh - Họ tên bn ................................................................... Ns: .................... Nam/Nữ - Địa chỉ: ...................................................................... Nghề nghiệp: .................. - Liên lạc: ..................................................................... ....................................... - Vào viện ngày ............................................... Số NV.......................................... - Chẩn đoán(*): ............................................................ khoa: .............................. - Tiêu chuẩn chẩn đoán: ............................................... ....................................... 2/ Yếu tố nguy cơ - Chiều cao:cm; cân nặng:cm - Vòng eocm; vòng hông:.cm - huyết áp tâm thu/tâm trương:../..mmHg; điều trị: ............................... - Hút thuốc lá: có/ không ; loại :.; điếu/ngày:.. - Uống rượu: có/không ; loại ...số lượng.. - Tiểu đường có/không ; típ: từ khi nào:..điều trị gì: . .......................................... ....................................... - Bệnh lý tim mạch, đột qụy................................. ; điều trị .......................... - Cha mẹ, anh chị em ruột bị tim mạch hay đột qụy ..................................... .lúc mấy tuổi ............................................................ - Các bệnh lý hiện tại khác (chú ý viêm nhiễm): .. ....................................... 3/ Thông tin bệnh lý: - Triệu chứng ....................................................... ....................................... ............................................................................... ....................................... - K/q men tim: ..................................................... ....................................... - K/q ECG ........................................................... ....................................... - Chụp mạch vành ................................................ ....................................... - Thường quy: ...................................................... ....................................... - Các k/q lipid: ..................................................... ....................................... - Homocystein: .................................................... IL6: ................................ - CRPhs ............................................................... PLAC test:..................... - Điện di LDL: ..................................................... ....................................... 4/ Các thông tin tái khám: L1 (ngày//.) ; v/đ .................................. ....................................... L2 (ngày//.) ; v/đ .................................. ....................................... L3 (ngày//.) ; v/đ .................................. ....................................... L4 (ngày//.) ; v/đ .................................. ....................................... L5 (ngày//.) ; v/đ .................................. ....................................... L6 (ngày//.) ; v/đ .................................. ....................................... L7 (ngày//.) ; v/đ .................................. ....................................... L8 (ngày//.) ; v/đ .................................. ....................................... L9 (ngày//.) ; v/đ .................................. ....................................... L10 (ngày//.) ; v/đ ................................ ....................................... L11 (ngày//.) ; v/đ ................................ ....................................... L12 (ngày//.) ; v/đ ................................ ....................................... 5/ Các ghi chú ..................................................................................... ....................................... ..................................................................................... ....................................... ..................................................................................... ....................................... ..................................................................................... ....................................... ..................................................................................... ....................................... Ngày...//.. (*): phải ghi cụ thể đau thắt ngực không ổn định không ST chênh lên, có ST chênh lên, nhồi máu cơ tim Phụ lục 2: MẪU ĐỒNG Ý THAM GIA NGHIÊN CỨU Tôi tên:................................................................................... Sinh năm:............................................................................... Hiện là bệnh nhân (thân nhân của bệnh nhân) đang điều trị tại khoa:....................................... Sau khi được bác sĩ điều trị giải thích đầy đủ về ý nghĩa của xét nghiệm và theo dõi trong nghiên cứu. Chúng tôi đồng ý tham gia nghiên cứu, chúng tôi đồng ý các bác sĩ tiến hành thực hiện nghiên cứu trên mẫu bệnh phẩm và theo dõi bệnh của tôi trong quá trình điều trị (thời gian 2 năm). TP.Hồ Chí Minh, ngày tháng năm Người bệnh/thân nhân bệnh nhân ký tên Phụ lục 3:

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